Mineralocorticoid receptor splice variants in different human tissues
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چکیده
منابع مشابه
Mineralocorticoid receptor splice variants in different human tissues.
The mineralocorticoid receptor (MR), a member of the steroid receptor family, acts as a transcription factor and mediates both aldosterone and cortisol effects. Aldosterone specificity in some tissues results from the inactivation of competing cortisol into cortisone by 11beta-hydroxysteroid dehydrogenase. In other tissues MR and the glucocorticoid receptor show overlapping physiological effect...
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Various attempts to detect human pituitary growth hormone-releasing hormone receptor (pGHRH-R) in neoplastic extrapituitary tissues have thus far failed. Recently, four splice variants (SVs) of GHRH-R have been described, of which SV1 has the highest structural homology to pGHRH-R and likely plays a role in tumor growth. The aim of this study was to reinvestigate whether human tumors and normal...
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ژورنال
عنوان ژورنال: European Journal of Endocrinology
سال: 1998
ISSN: 0804-4643,1479-683X
DOI: 10.1530/eje.0.1380702